A
large cadre of investigators at UNC pursues diverse research
questions addressing basic mechanisms of cellular signaling.
Broad areas of interest include:
-
Receptors
for extracellular hormones, neurotransmitters, growth
factors, cytokines/chemokines, extracellular matrix
components, and other stimuli
-
Heterotrimeric
and monomeric guanine-nucleotide binding proteins (“G
proteins”) and their enzymatic and ion-channel effectors
-
Protein
and lipid kinases and phosphatases
-
Ubiquitination
and other dynamic post-translational modifications
-
Cell cycle-related signaling machinery
-
Apoptosis and cell survival signaling pathways
Modes of study encompass bioinformatics/genome
data-mining, structural biology (NMR, X-ray crystallography),
proteomics/mass spectrometry, biochemistry/molecular pharmacology,
cell biology, model organism genetics, and animal/plant
models. This shared focus on cell signaling research brings
together UNC scientists from both basic science departments
and biomedical centers dedicated to specific diseases
as diverse as arthritis, cardiovascular diseases, cancer,
cystic fibrosis, and neurological disorders.
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