The Carolina Center of Cancer Nanotechnology Excellence is an NCI-funded collaboration between the University of North Carolina and the Lineberger Comprehensive Cancer Center. Our major goal is to design and fabricate novel and innovative, multifunctional nanodevices and then test their in vivo performance using sophisticated mouse models of human cancer. Our ultimate intent is translation to the clinic. In addition, this center will use breakthrough nanodevice fabrication technology to develop nanoscale tools for research and detection applications. In addition to general oncology applications, this CCNE will focus on leukemia; lymphoma; myeloma; and brain, breast, colon, and lung cancers.

Our goals include development of:

• Smart nanoparticles for cancer therapy and imaging
• Carbon nanotube x-ray devices for in vivo cancer detection and treatment
• Targeted magnetic nanoparticles for brain tumor imaging and therapy
• Chemically patterned nanoscale surfaces for capturing tumor cells
• Nanofluidic devices for rapid analysis of tumor cell signaling and migration

The C-CCNE features interactions among physical and biological scientists in a series of projects and cores that will work together to quickly harness innovations in nanotechnology for the early diagnosis and treatment of cancer. The PI of each Project and each Core is an outstanding investigator with great expertise in the relevant technology or biology. Please use the buttons to visit the home pages of the Projects and Cores for more information about the investigators and ongoing research of the C-CCNE. Upcoming events can be found on the News and Events link.