Ras oncoproteins function as GDP-GTP regulated binary off-on switches that regulate cytoplasmic signaling networks. The conformation of Ras “switches” as it cycles between the GDP-bound off and GTP-bound on state.

Our research centers on elucidating the mechanisms by which aberrant Ras and Rho small GTPase signaling promote cancer growth, with the long-term goal of developing Ras and Rho inhibitors for cancer treatment.