Selected Publications from the Pagano Lab
 
       2010
  • Ning S*, Pagano J.
    The A20 deubiquitinase activity negatively regulates ubiquitination-mediated LMP1 activation of IRF7.
    J Virol. 2010. (Epub ahead of print: April 14, 2010)
    Abstract|Full text (PDF)
    * Corresponding author
  • Bentz G*. Liu R*, Hahn A, Shackelford J, Pagano JS.
    Epstein-Barr virus immediate-early protein RTA negatively regulates interferon regulatory factors.
    Virology (In Press).
    Abstract|Full text
    (* Contributed equally)
     
  • Bheda A, Gullapalli A, Caplow M, Pagano JS, Shackelford J.
    Ubiquitin editing enzyme UCH L1 and microtubule dynamics: Implication in mitosis
    Cell Cycle. 2010 Mar 15;9(5). [Epub ahead of print]
    Abstract|Full text
.
       2009
  • Fu-Zhang Wang , Debasmita Roy, Edward Gershburg, Christopher Whitehurst, Dirk Dittmer, and Joseph S. Pagano
    Maribavir inhibits Epstein-Barr viral transcription in addition to viral DNA replication .
    Journal of Virology. 2009. (In press). Epub ahead of print on 16 September 2009

    Abstract|Reprint (PDF)
     
  • Anjali Bheda, Julia Shackelford, and Joseph S. Pagano
    Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes.
    PLoS ONE. 2009. 4(8): e6764
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  • Anjali Bheda, Wei Yue, Anuradha Gullapalli, Chris Whitehurst, Renshui Liu, Joseph S. Pagano, and Julia Shackelford
    Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling.
    PLoS ONE. 2009. 4(6): e5955
    Full Text (HTML)|Reprint (PDF)

  • K Endo, S Kondo, J Shackleford, T Horikawa, N Kitagawa, T Yoshizaki, M Furukawa, Y Zenand J S Pagano
    Phosphorylated ezrin is associated with EBV latent membrane protein 1 in nasopharyngeal carcinoma and induces cell migration
    Oncogene. 2009     . 28: 1725-1735
    Full Text (HTML)|Reprint (PDF)
     
  • Christopher Whitehurst, Shunbin Ning, Gretchen L. Bentz, Florent Dufour, Edward Gershburg, Julia Shackelford, Yves Langelier, and Joseph S. Pagano
    The EBV Deubiquitinating Enzyme, BPLF1, Reduces EBV Ribonucleotide Reductase Activity
    Journal of Virology. Epub ahead of print. Feb. 25, 2009
    Abstract|Reprint (PDF)
      
       2008
  • Shunbin Ning, Alex Campos, Bryant Darnay, Gretchen Bentz, Joseph Pagano.
    TRAF6 and the three C-terminal lysine sites on IRF7 are required for its activation by the TNFR family member LMP1.
    Molecular and Cellular Biology. 2008. 28(20): 6536-6546
    Abstract|Full Text (HTML)|Reprint (PDF)    
  • Gershburg E, Pagano JS
    Conserved herpesvirus protein kinases.
    Biochim Biophys Acta. 2008. 1784(1):203-12. Review.
    Full Text (HTML)|Reprint (PDF)
       2007
  • Jung JK, Arora P, Pagano JS, Jang KL.
    Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway.
    Cancer Res. 2007. 67(12):5771-8.
    Abstract|Full Text (HTML)|Reprint (PDF)
     PMID: 17575144
     
  • Ceccarelli S, Wakisaka N, Pagano JS, Torrisi, MR
    Epstein-Barr virus latent membrane protein 1 promotes concentration in multivesicular bodies of fibroblast growth factor 2 and its release through exosomes.
    International Journal of Cancer. 2007. 121(7): 1494-1506.
    Full Text (HTML)|Reprint (PDF)
     
  • Shackelford, J., Pagano, JS.
    Role of the ubiquitin system and tumor viruses in AIDS-related cancer.
    BMC Biochem. 2007 Nov 22;8 Suppl 1:S8. Review.
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 18047745
     
  • Pagano JS.
    Is Epstein-Barr virus transmitted sexually?
    J. Infect. Dis. 2007. 195(4):469-70. Epub 2007 Jan 10.
    Full Text (HTML)|Reprint (PDF)
     
  • Gershburg, E., Raffa, S., Torrisi, M. R. and J. S. Pagano
    Epstein-Barr virus-encoded protein kinase (BGLF4) is invovled in production of infectious virus.
    Journal of Virology. 2007. 81(10):5407-12.
    Abstract|Full Text (HTML)|Reprint (PDF)

  • Huye, L.*, Ning, S.*, Kelliher, M., Pagano, J.
    IRF7 is activated by a viral oncoprotein through RIP-dependent ubiquitination.
    Molecular and Cellular Biology. 2007. 27(8): 2910-2918.
    * Contributed equally to the work.
    Abstract|Full Text (HTML)|Reprint (PDF)

  • Horikawa T, Yang J, Kondo S, Yoshizaki T, Joab I, Furukawa M, Pagano JS.
    Twist and Epithelial-Mesenchymal Transition are Induced by the Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 and are Associated with Metastatic Nasopharyngeal Carcinoma.
    Cancer Res 2007. 67(5): 1970-1978
    Abstract|Full Text (HTML)|Reprint (PDF)

  • Kondo S, Yoshizaki T, Wakisaka N, Horokawa T, Murono S, Jang KL, Joab I, Pagano JS.
    MUC1 induced by Epstein-Barr Virus Latent Membrane Protein 1 Causes Dissociation of Cell-Matrix Interaction and cellular Invasiveness via STAT Signaling.
    J. Virol. 2007. 81(4): 1554-1562
    Abstract|Full Text (HTML)|Reprint (PDF)

 
       2006
  • Kondo S, Seo SY, Yoshizaki T, Wakisaka N, Furukawa M, Joab I, Jang KL, Pagano JS.
    EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells.
    Cancer Res. 2006 Oct 15;66(20):9870-7.
    Abstract|Reprint (PDF)
    PMID: 17047048


  • Yue, W., Shackelford, J., Pagano, JS.
    cdc2/cyclin B1-dependent phosphorylation of EBNA2 at Ser243 regulates its function in mitosis.
    J Virol. 2006 Feb; 80(4):2045-50.
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMCID:1367142

 
       2005
  • Jang, KL.*, Shackelford, J.*, Seo SY, Pagano, JS.
    Up-regulation of Beta-catenin by a viral oncogene correlates with inhibition of Siah-1 ubiquitin ligase in B-lymphoma cells.
    Proc Natl Acad Sci U S A. 2005, 102(51):18431-6.
    *Contributed equally to this work
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMCID:1317901


  • Hahn AM, Leslie HE, Ning SB, Pagano JS
    Interferon regulatory factor-7 is negatively regulated by the Epstein-Barr virus immediate-early gene, BZLF-1
    J Virol. 2005. 79(15):10040-10052
    Abstract|Full Text (HTML)|Reprint (PDF)


  • Yue, W., Gershburg, E., Pagano, J.S.
    Epstein-Barr Virus protein kinase phosphorylates EBNA2 and suppresses EBNA2 transactivation of the LMP1 promoter.
    J. Virol., 2005. 79(9): 5880-5885.
    Abstract|Full Text (HTML)|Reprint (PDF)

  • Shackelford J., Pagano JS.
    Targeting of host-cell ubiquitin pathways by viruses.
    In Essays in Biochemistry, 2005 41: 139-156. Portland Press Ltd. London, UK.
    Abstract

  • Wakisaka, N., Yoshizaki, T., Murono, S., Furukawa, M., Raab-Traub, N., Pagano, J.S.
    Ribonucleotide reductase inhibitors enhance cidofovir-induced apoptosis in EBV-positive nasopharyngeal carcinoma xenografts.
    Int. J. Cancer. 2005. 116: 640-645
    Abstract|Full Text (HTML)|Reprint (PDF)

  • Kondo S, Wakisaka N, Schell MJ, Horikawa T, Sheen TS, Sato H, Furukawa M, Pagano JS, Yoshizaki T.
    Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: Enhanced susceptibility to nasopharyngeal carcinoma.
    Int. J. Cancer, 2005. 115(3):368-376
    Abstract|Full Text (HTML)|Reprint (PDF)

  • Yoshizaki, T., Wakisaka, N. and Pagano, J.S.
    Epstein-Barr virus invasion and metastasis.
    2005. Chapter 12. in: Epstein-Barr virus. Ed. by E. Robertson. Caister Academic, Norfolk, England. 171-196.
    Abstract|Full Text (HTML)|Reprint (PDF)

  • Pagano, J. S.
    Infectious Mononucleosis.
    In: PIER [Online database], 2005. Philadephia. American College of Physicians.
    Full Text [login required]

 
       2004
  • Qing,J., C. Liu, L. Choy, RY Wu, J.S. Pagano, R. Derynck.
    TGF-b/Smad3 signaling regulates IRF-7 function and transcriptional activation of the interferon-beta promoter.
    Mol. Cell Biol. 24:3:1411-1425,2004.
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 14729983

  • Zhang, L., J. Zhang, Q. Lambert, C.J. Der, J.S. Pagano.
    Interferon Regulatory Factor 7 is associated with EBV-transformed CNS lymphoma andhas Oncogenic Properties.
    J. Virol, 78:23:12987-12995, 2004.
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 15542650

  • Wang L, Wakisaka N, Tomlinson CC, DeWire SM, Krall S, Pagano JS, Damania B
    The Kaposi's Sarcoma-Associated Herpesvirus (KSHV / HHV-8) K1 Protein Induces Expression of Angiogenic and Invasion Factors
    Cancer Res. 2004 Apr;64(8):2774-81
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 15087393

  • Zhang L, Hong K, Zhang J, Pagano JS
    Multiple Signal Transducers and Activators of Transcription (STATs) are Induced by EBV LMP-1
    Virology. 323(1): 141-152 , 2004
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 15165826

  • Shackelford J, Pagano JS
    Tumor Viruses and Cell-Signaling Pathways: Deubiquitination versus Ubiquitination
    Mol. Cell Biol.24(12): 5089-5093, 2004
    Full Text (HTML)|Reprint (PDF)
    PMID: 15169876

  • Wakisaka N, Kondo S, Yoshizaki T, Murono S, Furukawa M, Pagano JS
    Epstein-Barr Virus Latent Membrane Protein 1 Induces Synthesis of Hypoxia-Inducible Factor 1α
    Mol. Cell Biol. 24(12): 5223-34, 2004
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 15169887

  • Gershburg E, Hong K, Pagano JS
    Effects of Maribavir and Selective Indolocarbazoles on the Epstein-Barr Virus Protein Kinase BGLF4 and on Viral Lytic Replication
    Antimicrob Agents Chemother. 2004 May; 48(5):1900-3
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 15105156

  • Yue W, Davenport MG, Shackelford J, Pagano JS
    Mitosis-Specific Hyperphosphorylation of the Epstein-Barr Virus Nuclear Antigen 2 (EBNA-2) Suppresses its Function
    J Virol. 2004 Apr;78(7):3542-52
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 15016877
     
  • Pagano, JS, Blaser, M., Buendia, M-A, Damania, B., Khalili, K., Raab-Traub, N, Roizman, B.
    Infectious agents and cancer: criteria for a causal relation.
    Seminars in Cancer Biology, 14:453-471, 2004.
    Abstract
    PMID: 15489139

 
       2003
  • Shackelford J, Maier C, Pagano JS
    Epstein-Barr Virus Activates β-Catenin in Type III Latently Infected B-Lymphocyte Lines: Association with Deubiquitinating Enzymes
    Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15572-15576
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 14663138

  • Ning SB, Hahn AM, Huye L, Pagano JS
    Interferon Regulatory Factor 7 Regulates Expression of Epstein-Barr Virus Latent Membrane Protein 1: A Regulatory Circuit
    J Virol. 2003; 77(17):9359-9368
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 12915551
     

 
       2002
  • Wakisaka N, Murono S, Yoshizaki T, Furukawa M, Pagano JS
    Epstein-Barr Virus Latent Membrane Protein 1 Induces and Causes Release of Fibroblast Growth Factor 2
    Cancer Res. 2002 Nov 1;62(21):6337-44
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 12414666
     
  • Pagano JS
    Viruses and Lymphomas
    N Engl J Med. 2002 Jul 11;347(2):78-9
    Full Text (HTML) |Reprint (PDF)
    PMID: 12110734
     
  • Gershburg E, Pagano JS
    Phosphorylation of the Epstein-Barr Virus DNA Polymerase Processivity Factor by the EBV-Encoded Protein Kinase and Effects of the L-Riboside Benzimidazole 1263W94
    J Virol. 2002 Feb:76(3):998-1003
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 11773375

  • Wong M, Pagano JS, Schiller J, Tevethia S, Raab-Traub N, Gruber J.
    Commentary: new associations of human papillomavirus, Simian Virus 40, and Epstein-Barr virus with human cancer.
    J. NCI. 2002. 94(24): 1832-1836.
    Abstract|Full Text (HTML)|Reprint (PDF)

 
       2001
  • Zhang L, Wu LH, Hong K, Pagano JS
    Intracellular Signaling Molecules Activated by Epstein-Barr Virus for Induction of Interferon Regulatory Factor 7
    J Virol. 2001 Dec:75(24):12393-401
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 11711629

  • Murono S, Raab-Traub N, Pagano JS
    Prevention and Inhibition of Nasopharyngeal Carcinoma Growth by Antiviral Phosphonated Nucleoside Analogs
    Cancer Res. 2001 Nov1;61(21):7875-7877
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 11691806

  • Zhang L, Pagano JS
    Interferon Regulatory Factor 7 Mediates Activation of Tap-2 by Epstein-Barr Virus Latent Membrane Protein 1
    J Virol. 2001 Jan;75(1):341-50
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 11119603

  • Sun N, Pagano JS.
    Epstein-Barr Virus.
    2001. In: Encyclopedia of Life Sciences. Nature Publising Group. Macmillan Publishers Ltd. London.
    Abstract|Full Text (HTML)|Reprint (PDF)

 
       2000
  • Murono S, Yoshizaki T, Sato H, Takeshita H, Furukawa M, Pagano JS
    Aspirin Inhibits Tumor Cell Invasiveness Induced by Epstein-Barr Virus Latent Membrane Protein 1 through Suppression of Matrix Metalloproteinase-9 Expression
    Cancer Res. 2000 May 1;60(9):2555-61
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 10811139

  • Zhang L, Pagano JS
    Interferon Regulatory Factor 7 Is Induced by Epstein-Barr Virus Latent Membrane Protein 1
    J Virol. 2000 Feb;74(3):1061-68
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 10627515

 
       Before 2000
  • Zhang L, Pagano JS
    Interferon Regulatory Factor 2 Represses the Epstein-Barr Virus BamHI Q Latency Promoter in Type III Latency
    Mol Cell Biol. 1999 Apr;19(4):3216-23
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 10082588

  • Yoshizaki T, Sato H, Furukawa M, Pagano JS
    The Expression of Matrix Metalloproteinase 9 is Enhanced by Epstein-Barr Virus Latent Membrane Protein 1
    Proc Natl Acad Sci USA. 1998 Mar 31;95(7):3621-6
    Abstract|Full Text (HTML)|Reprint (PDF)
    PMID: 9520415

  • Zhang L, Pagano JS
    IRF-7, a New Interferon Regulatory Factor Associated With Epstein-Barr Virus Latency
    Mol Cell Biol. 1997 Oct;17(10):5748-57
    Abstract|Reprint (PDF)
    PMID: 9315633