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| John F. Boggess, M.D.
Associate Professor |  |
Clinical Interests
Dr. Boggess has developed a minimally invasive surgery program in Gynecology Oncology at UNC. Patients with invasive uterine cancer can be treated and staged using "bandaid" incisions which minimizes their recovery time significantly. Dr. Boggess continues to be actively involved in the comprehensive management of women with gynecologic malignancies and in the training of oncology fellows.
Research Interests
Dr. Boggess is currently focused on developing a comprehensive cervical cancer prevention program at UNC. Over the last three years, Dr. Boggess, a practicing gynecologic oncologist, has been investigating novel biomarkers for cervical cancer development. With the addition of a digital colposcopy facility and a growing laboratory, Dr. Boggess has been able to succesfully complete a translational research protocol evaluating telomerase activity and cervical cancer development in 120 women with abnormal Pap smears. In collaboration with Dr. William Kaufmann of the Department of Pathology, Dr. Boggess is also investigating the genetic events which can lead to cancer and their relationship to oncogenic viral infection. This work has laid the foundation for collaboration with the Center for AIDS Research to investigate telomerase and cervical carcinogenesis in HIV infected women.
Secondly, Dr Boggess' lab is investigating the regulation of telomerase in endometrium and its potential role in endometrial carcinogenesis. Ongoing investigations looking at telomerase and PTEN and their roles in cancer development include both basic science and clinical translational programs.
Dr. Boggess is a member of the Cancer Prevention and Control Committee, a branch of the Gynecologic Oncology Group (a national cooperative group funded by the NCI). Though his involvement with this committee, Dr. Boggess is helping develop treatment protocols for studying vaccination and medical treatments for cervical dysplasia patients.
Dr. Boggess is involved on a daily basis with exposing medical students, residents and oncology fellows to the relationship laboratory science can have with clinical medicine and mentoring projects that seek to answer clinical questions with the help of epidemiology and molecular biology.
Training
Oregon Health Sciences University, Portland, OR M.D. 1991 Medicine
University of Washington, Seattle, WA Residency 1991-1995 OB/GYN
University of North Carolina, Chapel Hill, NC Fellowship 1995-1998 Gyn Onc
Board Certifications
Gynecologic Oncology 1998
Obstetrics and Gynecology 1995
Publications
Boggess, J.F., J. Watson, B.A. Lessey, L. Van Le, W.C. Fowler, Jr., S. Haskill. 1997. a 2b 1 integrin expression and tumorigenicity: immortalization of human granulosa cells and comparison with normal and neoplastic cells. Gynecol. Oncol. 64, Abstract #218.
Boggess, J.F., N. Gould, B.A. Lessey, L. Van Le. 1997. Integrin expression analysis suggests that granulosa cell tumors are epithelial neoplasms. J. Soc. Gynecol. Invest. 4, Abstract #578.
Boggess, J.F., J. Watson, B.A. Lessey, L. Van Le, W.C. Fowler, Jr., S. Haskill. 1997. Inverse correlation between a 2b 1 integrin expression and tumorigenicity in human granulosa cell lines. Amer. Assoc. Cancer Res., Abstract #954.
Boggess, J.F., B.A. Goff, J.M. Cain, B.E. Greer, M.R. Soules, H.K. Tarnirni. 1997. Serum inhibin and disease status in women with ovarian granulosa cell tumors. Gynecol. Oncol. 64, 64-67.
Boggess, J.F. 1997. Should I use Papnet for cervical screening? Current Prac. (UNC School of Medicine), 17.
Boggess, J.F., Lamarque, L.R., Morrissey, T.P., Roayaei, J.A., Lessey, B.A., 2000. Telomerase expression in exfoliated cervical cells correlates with known cervical cancer risk factors. Society of Gynecologic Oncologists, Abstract #247.
Boggess, J.F., Williams, C., Lamarque, L.R., Meyer, W.R., Murray, M.J., Lessey, B.A. 2000. Dynamic expression of endometrial telomerase in the luteal phase. Society of Gynecologic Investigation, Abstract #251174.
Boggess, J.F., Daniel, S., Lamarque, L.R., Walton, L.A., Van Le, L. 2000. HGSIL cervical smears: can we omit colposcopy? American College of Obstetricans and Gynecologists, Abstract.
J.F.Boggess, L. Robert Lamarque, K. L. Price, T. P. Morrissey, R. A. Lininger, W. K. Kaufmann. Genetic Instability and Telomerase Expression in HPV Induced High Grade Cervical Dysplasias. Geron Symposium #3, Telomerase and Telomere Dynamics in Cancer and Aging, 2000.
P. A. Gehrig, J.F. Boggess, D.W. Ollila, P.A. Groben, L. Van Le. Advanced Appendiceal Carcinoma Mimicking Ovarian Cancer. ACOG District 4, 2000.
David H Moore, Richard P McQuellon, John A Blessing, Jo Benda, David S Miller, George Olt, Stephanie King, John F Boggess, Thomas F Rocereto, A Randomized Phase III Study of Cisplatin Versus Cisplatin Plus Paclitaxel in Stage IVB, Recurrent or Persistant Squamous Cell Carcinoma of the Cervix. Society of Gynecologic Oncologists, 2001, Abstract #5.
David M Boruta II, Linda Van Le, Wesley C Fowler Jr, Paola A Gehrig, John F Boggess, Leslie A Walton, Weekly Paclitaxel Infusion as Salvage Therapy in Ovarian Cancer. Society of Gynecologic Oncologists, 2001, Abstract #152.
10058 Telomerase Activity and hTERT Gene Expression Increase with Dysplastic Cervical Change. poster presentation at the 33rd Annual Meeting of theSGO, Miami Beach, Florida,
March 16-20, 2002.
100311 Estrogen induction of telomerase activity by Mitogen-Activiated Kinase-dependent
pathways in human endometrial carcinoma cells . poster presentation at the 33rd Annual Meeting of the SGO, Miami Beach, Florida, March 16-20, 2002.
100555 Estrogen mediates regulation of the telomerase catalytic subunit gene (hTERT) in
endometrial cancer cell lines in an estrogen receptor-a dependent manner. poster presentation at the 33rd Annual Meeting of the SGO Miami Beach, Florida, March 16-20, 2002.
E-mail: jboggess@med.unc.edu
Telephone: (919) 966-5996
Address: 4014 Old Clinic Bldg Chapel Hill, NC
