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Last Updated: 4/26/2008
| Mark C. Weissler, M.D.
Professor |  |
Clinical Interests
Head & Neck Cancer
Oral Cancer
Larynx Cancer
Oropharyngeal Cancer
Hypopharyngeal Cancer
Salivary Cancer
Thryoid and parathyroid disease and cancer
Laryngeal stenosis
Tracheal stenosis
Skull base surgery
Sinonasal Cancer
Research Interests
Dr. Weissler is involved in the clinical study of Head and Neck Cancer. He was Co-Investigator on The Carolina Head and Neck Cancer Study (CHANCE), which is a population-based case-control study of head and neck cancer in a 46-county region of North Carolina. The study aims to evaluate the relationship between polymorphisms of diverse genes that, in combination with exposure to tobacco and alcohol, modify the risk of head and neck cancer. He works closely with the Head and Neck Multidisciplinary Team on multiple clinical trials utilizing new chemotherapy and radiation protocols for the treatment of Head and Neck Cancer including the use of intraoperative radiation therapy and the Cyberknife.
Recent Accomplishments and Honors
Dr. Weissler was elected a Regent of the American College of Surgeons this past year.
Training
Boston University Six Year Medical Program BA, MD 1980
Harvard University, Massachusetts General Hospital General Surgery 1980-1982
Harvard University, Massachusetts Eye & Ear Infirmary Otolaryngology 1982-1985
University of Cincinnati Fellowship in Head & Neck Oncology 1985-1986
Board Certification:
Otolaryngology 1985
Publications
Journals:
Olshan AF, Weissler MC, Watson MA, Bell DA. GSTM1, GSTT1, GSTP1, CYP1A1, and NAT1 polymorphisms, tobacco use, and the risk of head and neck cancer. Cancer Epidemiology, Biomarkers & Prevention. 9, 185-199, February 2000.
Mukherji SK, O'Brien SM, Gerstle RJ, Weissler MC, Shockley WW, Stone JA, Castillo M. The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx. Head & Neck, 22: 282-287, May 2000.
Olshan AF, Weissler MC, Watson MA, Bell DA. Risk of head and neck cancer and the alcohol dehydrogenase 3 genotype. Carcinogenesis, 22(1):57-61, 2001.
Clark JM, Weissler, MC. Localized laryngotracheobronchial amyloidosis: Case report and review of the literature. Ear Nose Throat J. 80(9): 632-638.
Poole ME, Sailer SL, Rosenman JG, Tepper JE, Weissler MC, Shockley WW, Yarbrough WG, Pillsbury HC, Schell MJ, Bernard SA. Chemoradiation for Locally Advanced Squamous Cell Carcinoma of the Head and Neck for Organ Preservation and Palliation. Arch Otolaryngol Head Neck Surg, 127:1446-1450, Dec 2001.
Olshan AF, Watson MA, Weissler MC, Bell DA. XRCCI polymorphisms and head and neck cancer. Cancer Letters 2002; 178:181-186.
Geisler SA, Olshan AF, Weissler MC, Jainwen C, Funkhouser WK, Smith J, Vick K. p16 and p53 protein expression as prognostic indicators of survival and disease recurrence from head and neck cancer. Clinical Cancer Research 2002;8:3445-53.
Yu KK, White DR, Weissler MC, Pillsbury HC. Nontraumatic Atlantoaxial Subluxation (Grisel Syndrome): A Rare Complication of Otolaryngological Procedures. Laryngoscope 2003; 6:1047-1049.
Contributions to Textbooks:
Weissler MC. Cancer of the Larynx and Hypopharynx. In: Morris PJ, Wood WC (eds.). Oxford Textbook of Surgery, 2nd edition. Oxford: Oxford University Press; 2000: 2939-2952.
Weissler MC. Tracheotomy and Intubation. In: Bailey BJ, Johnson JT, Jackler RK, Pillsbury HC, Tardy ME (eds.). Head and Neck Surgery-Otolaryngology, 3rd edition, Vol. 1. Philadelphia: JB Lippincott Company; 2001:677-689.
Weissler MC. Chapter 11: Hoarseness. In: Netter’s Internal Medicine. Marschall and Greganti (eds.). Teterboro, New Jersey: Icon Learning Systems, 2003, pp. 58-64.
Weissler MC. Chapter 12:Neck Masses in Adults. In: Netter’s Internal Medicine. Marschall and Greganti (eds.). Teterboro, New Jersey: Icon Learning Systems, 2003, pp.
65-69.
1: Related Articles, LinksLee SC, Shores CG, Weissler MC.
Salvage surgery after failed primary concomitant chemoradiation.
Curr Opin Otolaryngol Head Neck Surg. 2008 Apr;16(2):135-40. Review.
PMID: 18327032 [PubMed - indexed for MEDLINE]2: Related Articles, LinksRichey LM, George JR, Couch ME, Kanapkey BK, Yin X, Cannon T, Stewart PW, Weissler MC, Shores CG.
Defining cancer cachexia in head and neck squamous cell carcinoma.
Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6561-7.
PMID: 18006755 [PubMed - indexed for MEDLINE]3: Related Articles, LinksRichey LM, Shores CG, George J, Lee S, Couch MJ, Sutton DK, Weissler MC.
The effectiveness of salvage surgery after the failure of primary concomitant chemoradiation in head and neck cancer.
Otolaryngol Head Neck Surg. 2007 Jan;136(1):98-103.
PMID: 17210342 [PubMed - indexed for MEDLINE]4: Related Articles, LinksRichey LM, Olshan AF, George J, Shores CG, Zanation AM, Cannon T, Weissler MC.
Incidence and survival rates for young blacks with nasopharyngeal carcinoma in the United States.
Arch Otolaryngol Head Neck Surg. 2006 Oct;132(10):1035-40.
PMID: 17043247 [PubMed - indexed for MEDLINE]5: Related Articles, LinksArdeshirpour F, Ebert CS Jr, Dubin MG, Weissler MC.
Radiology quiz case 2. Maxillary osteomyelitis.
Arch Otolaryngol Head Neck Surg. 2006 Jun;132(6):691, 693. No abstract available.
PMID: 16785419 [PubMed - indexed for MEDLINE]6: Related Articles, LinksCannon T, Zanation AM, Lai V, Weissler MC.
Nasopharyngeal carcinoma in young patients: a systematic review of racial demographics.
Laryngoscope. 2006 Jun;116(6):1021-6.
PMID: 16735924 [PubMed - indexed for MEDLINE]7: Related Articles, LinksGross RD, Steinhauer KM, Zajac DJ, Weissler MC.
Direct measurement of subglottic air pressure while swallowing.
Laryngoscope. 2006 May;116(5):753-61.
PMID: 16652083 [PubMed - indexed for MEDLINE]8: Related Articles, LinksZanation AM, Sutton DK, Couch ME, Weissler MC, Shockley WW, Shores CG.
Use, accuracy, and implications for patient management of [18F]-2-fluorodeoxyglucose-positron emission/computerized tomography for head and neck tumors.
Laryngoscope. 2005 Jul;115(7):1186-90.
PMID: 15995504 [PubMed - indexed for MEDLINE]9: Related Articles, LinksHudgins PA, Kingdom TT, Weissler MC, Mukherji SK.
Selective neck dissection: CT and MR imaging findings.
AJNR Am J Neuroradiol. 2005 May;26(5):1174-7.
PMID: 15891180 [PubMed - indexed for MEDLINE]10: Related Articles, LinksZajac DJ, Weissler MC.
Air pressure responses to sudden vocal tract pressure bleeds during production of stop consonants: new evidence of aeromechanical regulation.
J Speech Lang Hear Res. 2004 Aug;47(4):784-801.
PMID: 15324286 [PubMed - indexed for MEDLINE]11: Related Articles, LinksWeissler MC, Scharer S.
What's new in otolaryngology--head and neck surgery.
J Am Coll Surg. 2004 Jul;199(1):114-23. Review. No abstract available.
PMID: 15217639 [PubMed - indexed for MEDLINE]12: Related Articles, LinksChung CH, Parker JS, Karaca G, Wu J, Funkhouser WK, Moore D, Butterfoss D, Xiang D, Zanation A, Yin X, Shockley WW, Weissler MC, Dressler LG, Shores CG, Yarbrough WG, Perou CM.
Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression.
Cancer Cell. 2004 May;5(5):489-500.
PMID: 15144956 [PubMed - indexed for MEDLINE]13: Related Articles, LinksGaudet MM, Olshan AF, Poole C, Weissler MC, Watson M, Bell DA.
Diet, GSTM1 and GSTT1 and head and neck cancer.
Carcinogenesis. 2004 May;25(5):735-40. Epub 2003 Dec 19.
PMID: 14688020 [PubMed - indexed for MEDLINE]
E-mail: Mark_Weissler@med.unc.edu
Telephone: (919) 843-3796
FAX: (919) 843-4750
Address: G0412 Neurosciences Hospital. UNC, CB #7070 Chapel Hill, NC 27599-7070
