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| Benjamin F. Calvo, M.D.
Associate Professor |  |
Research Interests
Dr. Calvo's research focuses on non-receptor protein-tyrosine kinases (PTKs), which are important in signal transduction from cytoskeletal structures. He is also intesested in the EGFR family of receptor tyrosine kinases as they relate to solid malignancies. He is actively pursuing the use of quantitative PCR and biochip technology to determine mRNA levels of these various kinases in carcinomas of the colon, breast and melanomas. Dr. Calvo has been actively involved in the development of new techniques for cyroablation of liver metastases from colon cancer as well as participating in a number of active multi-modality therapeutic programs for patients with colon and rectal carcinoma.
Dr. Calvo is taking the lead, in conjunction with Dr. Mark Graham from Medical Oncology and Dr. Robert Briggaman from Dermatology, in developing a melanoma program at UNC. Their work will focus on the development of combined chemotherapy and biologic treatments along with novel immunologic strategies that will include vaccine and antibody based efforts.
Publications
Calvo B, Kashmiri SV, Hutzell P, Hand PH, Slavin-Chiorini DC, Schlom J, ZarembaS, Construction and purification of domain-deleted immunoglobulin variants of the recombinant/chimeric B72.3 (y1) monoclonal antibody. Cancer-Biother. 1993;Spring. 8(1); 95-109.
Scanlan MJ, Raj BK, Calvo B, Garin Chesa P, Sanz Moncasi MP, Healey JH, Old LJ, Rettig WJ, Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc Natl Acad Sci USA, 1994;91(12);5657-61.
Semelka R, Kelekis NL, Molina PL, Sharp T, Calvo B, Pancreatic masses with inconclusive findings on spiral CT: Is there a role for MRI? JMRI, 1996:585-588
Hong Yu, Xiong Li, Gail S Marchetto, Ruth Dy, Deborah Hunter, Benjamin Calvo, Tom L Dawson, Matthias Wilm, Robert J. Anderegg, Lee M. Graves and H. Shelton Earp, Activation of a Novel Calcium-dependent Protein-tyhrosine Kinase Journal of Biological Chemistry,1996;271(47);29993-29998.
Benjamin F. Calvo, and Richard C. Semelka. Beyond Anatomy, MRI as a Molecular Diagnostic Tool in Surgical Oncology Clinics of North America, 8(1), Scott H. Kurtzman (ed.), pg. 171-183, January 1999.
Ikawa H., Kamitani H., Calvo B.F., Foley J.F., and Elling T.E. Expression of 15-Lipoxygenase-1 in Human Colorectal Cancer. Cancer Res., 59:360-366, 1999.
E-mail: calvo@med.unc.edu
Telephone: (919) 966-4416
Address: 3010 Old Clinic Bldg Chapel Hill, NC
