Research Interests
Bonnie C. Yankaskas, Ph.D. directs the Carolina Mammography Registry (CMR), which was funded by DOD in 1994 and NCI since 1995 to study the practice of and outcomes from breast cancer screening mammography at the community level. A mammography and a pathology database are being built from primary data collected in the community. Data is being prospectively collected directly from mammography facilities including demographic data, breast history data, reason for and findings on the screening mammogram, data on other radiologic studies necessary to resolve the screening assessment and recommendations for follow-up. Cancer pathology data is received from pathology laboratories, from mammography practices and from the NC Central Cancer Registry. Breast cancer and breast benign pathology data are collected. Outcome data in the pathology database include date and type of pathology, method of biopsy, date of biopsy and breast site, number of nodes tested and number positive, estrogen and progesterone receptor status, tumor grade and stage. At the end of June 2003, there were 80 facilities actively participating in the project. There were just over 1,013,000 records among 429,250 individual women who reside in North Carolina and have their screening mammograms in facilities located in 39 counties in NC.
The project is presently funded through 2005. The emphasis for this funding cycle is for studying mammography use and breast cancer survival in Native American women in NC. Work continues evaluating performance of mammography under different circumstances, in different settings, in different populations. Information on the Registry can be found at http://cmr.unc.edu/.
The Registry is part of the National Breast Cancer Surveillance Consortium (BCSC) and national research projects are also in progress. In addition, work continues as part of the International Breast Cancer Screening Network to evaluate the feasibility of comparison of international breast cancer screening mammography performance. More information on the BCSC can be found at: http://breastscreening.cancer.gov/
Colorectal Screening

Dr. Yankaskas is working in collaboration with David F. Ransohoff, MD, a gastroenterologist at UNC, to study the practice of surveillance colonoscopy after finding a polyp on screening, in community practice. This work is funded for April 2004 - March 2007. Dr. Ransohoff is PI, Dr. Yankaskas is co-PI. The CMR will be the core center to support this new community-based work.

Publications
1. Yankaskas BC, Staab EV, Rudnick SA, Fletcher RH. The Radiologic Diagnosis of Pancreatic Cancer: the Effect of New Imaging Techniques. Invest Radiol 1985;20:73-8
2. Cuttino JT, Yankaskas BC, Hoskins EOL. Screen-film Mammography Versus Xeromammography in the Detection of Breast Cancer. Br J Radiol 1986;59:1159-62
3. Yankaskas BC, Knelson MH, Abernethy ML, Cuttino JT, Clark RL. Needle Localization Biopsy of Occult Lesions of the Breast: Experience in 199 Cases. Invest Radiol 1988;23:729-33
4. Parker LA, McPhail AH, Yankaskas BC, Mauro MA. Computed Tomography in the Evaluation of Clinical Stage IB Carcinoma of the Cervix. Gynecol Oncol 1990;37:332-4
5. Allard P, Yankaskas BC, Fletcher RH, Parker LA, Halvorsen RA. Sensitivity and Specificity of Computed Tomography for the Detection of Adrenal Metastatic Lesions Among 91 Autopsied Lung Cancer Patients. Cancer 1990;66:457-62
6. Schiebler ML, Yankaskas BC, Tempany C, Spritzer CE, Rifkin MD, Pollack HM, Holtz P, Zerhouni EA. Comparison of Reader Accuracy and Inter-Reader Variation in Staging Adenocarcinoma of the Prostate by Body Coil MRI: 100 Consecutive Radical Retropubic Prostatectomy Patients. AJR 1991; 158:559-62
7. Schiebler ML, Yankaskas BC, Tempany CT, Holtz P, Zerhouni E. Efficacy of Prostate-specific Antigen and Magnetic Resonance Imaging in Staging Stage C. Adenocarcinoma of the Prostate. Invest Radiol 1992; 7:575-77
8. Bird RE, Wallace TW, Yankaskas BC. Analysis of Cancers Missed at Screening Mammography. Radiology 1992;184:613-17
9. Slonim SM, Cuttino Jr, JT, Johnson CJ, Yankaskas BC, Smith III JJ, Silverman ML, Libertino JA. Diagnosis of Prostactic Carcinoma: Value of Random Transrectal Sonographically Guided Biopsies. AJR, 1993;161:1003-06
10. Pisano EP, Yankaskas BC, Ghate SV, Plankey MW, Morgan JT. Patient Compliance in Mobile Screening Mammography. Academic Radiology 1995; 2:1067-72
11. Mukherji SK, Weeks S, Castillo M, Yankaskas BC, Krishnan AG. Can CT Predict Invasion of the Lingual Neurovascular Bundle by Squamous Cell Carcinomas Arising from the Oral Cavity and Tongue Base? Radiology 1996; 198:157-62
12. Yankaskas BC, Jones MB, Aldrich TE. The Carolina Mammography Registry: A Population-Based Mammography and Cancer Surveillance Project. J Registry Management 1996; 23:175-78
13. Ballard-Barbash R, Taplin SH, Yankaskas BC, Ernster VL, Rosenberg RD, Carney PA, Geller BM, Kerlikowske K, Edwards BK, Lynch CF, Urban N, Chrvala CA, Key CR, Poplack SP, Worden JK, Kessler LG. Breast Cancer Surveillance Consortium: A National Mammography Screening and Outcomes Database. AJR 1997; 169:1001-1008
14. Heinzen MT, Yankaskas BC, Kwok RK. Comparison of Woman-specific versus Breast -specific Data for Reporting Screening Mammography Performance. Acad Radiol 2000; 7:232-236
15. Carney PA, Geller BM, Mofett H, Ganger M, Sewell M, Barlow WE, Stalnaker N, Taplin SH, Sisk C, Ernster VL,Wilkie HA, Yankaskas B, Poplack SP, Urban N, West MM, Rosenberg RD, Michael S, Mercurio TD, Ballard-Barbash R. Current Medicolegal and Confidentiality Issues in Large Multicenter Research Programs. Am J Epidemiol 2000; 152:371-8
16. Rosenberg RD, Yankaskas BC, Hunt WC, Ballard-Barbash R, Urban N, Ernster VL, Kerlikowske K, Geller B, Carney PA, Taplin S. Effect of Variations in Operational Definitions on Performance Estimates for Screening Mammography. Acad Radiol 2000;7:1058-68
17. Kwok RK, Yankaskas BC. The Use of Census Data to Determine an Individual's Socio-Economic Status: Validation Study. Ann Epidemiol 2001:11:171-177.
18. Yankaskas BC, Schell MJ, Bird RE, Desrochers DA. Reassessment of Missed Cancers from the Routine Practice of Screening Mammography: A Community-Based Study. AJR 2001;177:535-41..
19. Yankaskas BC, Cleveland RJ, Schell MJ, Kozar RC. Association of Sensitivity and Positive Predictive Values to Recall Rates from Screening Mammography. AJR. AJR 2001; 177:543-49.
20. Taplin SH, Ichikawa LE, Kerlikowske K, Ernster VL, Rosenberg RD, Yankaskas BC, Carney PA, Geller BM, Urban N, Dignan MB, Barlow WE, Ballard-Barbash R, Sickles EA. Concordance of Breast Imaging Reporting and Data System Assessments and Management Recommendations in Screening Mammography. Radiology 2002;222:529-45.
21. Geller BM, Barlow WE, Ballard-Barbash R, Ernster VL, Yankaskas BC, Sickles EA, Carney PA, Dignan MB, Rosenberg RD, Urban N, Zheng Y, Taplin SH. Use of the American College of Radiology BI-RADS to Report on the Mammographic Evaluation of Women with Signs and Symptoms of Breast Disease Radiology 2002;222:536-542.
22. Barlow WE, Lehman CD, Zheng Y, Ballard-Barbash R, Yankaskas BC, Cutter G, Carney PA, Geller BM, Rosenberg R, Kerlikowske K, Weaver DL, Taplin SH. Performance of Diagnostic Mammography for Women with Breast signs or Symptoms. . J Natl Cancer Inst 2002;94:1151---9
23. Ernster VL, Ballard-Barbash R, Barlow WE, Zheng Y, Weaver D, Cutter G, Yankaskas BC, Rosenberg R, Carney PA, Kerlikowske K, Taplin S, Urban N, Geller B. Detection of DCIS in Women Undergoing Screening Mammography. In press, JNCI 2002;94: .
24. Carney PA, Miglioretti DL, Yankaskas BC, Kerlikowske K, Rosenberg R, Rutter C, Geller BM, Abraham LA, Dignan M, Cutter G, Ballard-Barbash R. Individual and combined effects of age, breast density and hormone replacement therapy use on the performance of screening mammography. Ann Intern Med. 2003 Feb 4;138(3):168-75.
25. Yankaskas BC, Taplin SH, Ichikawa L, Geller BM, Rosenberg RD, Carney PA, Kerlikowske K, Ballard-Barbash R, Cutter G, Barlow WE. Effect of Screening Interval on Mammography Performance in the US. Submitted, Annals of Internal Medicine, May 2003.
26. Geller, BM, Kerlikowske K, Carney PA, Abraham LA, Yankaskas BC, Taplin SH, Ballard-Barbash R, Dignan MB, Rosenberg R, Urban N, Barlow WE. Mammography Surveillance Following Breast Cancer. In press Breast Cancer Research and Treatment, July 2003.
27. Kerlikowske, K, Miglioretti KL, Ballard-Barbash R, Weaver DL, Buist DSM, Barlow, WE, Carney PA, Cutter G, Geller BM, Rosenberg R, Yankaskas B, Taplin SH. Prognostic Characteristics of Breast Cancer in Postmenopausal Hormone Users and Non-Users in a Screening Population. Accepted JNCI, August 2003.
28. Gill KS, Yankaskas BC. Racial Differences in Mammography Screening Performance. Accepted Cancer, August 2003.

E-mail: bcy@med.unc.edu
Telephone: (919) 966-6936
FAX: (919) 966-0525
Address: 106 Mason Farm Rd., CB# 7515 Chapel Hill, NC

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