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| Matthew G. Ewend, M.D.
Associate Professor |  |
Clinical Interests
Metastatic brain tumors, pituitary tumors, primary brain tumors.
Research Interests
The neuro-oncology research laboratory, under the direction of Dr. Matthew Ewend, is primarily focused on two areas of research. The first involves the development of new treatments for metastatic brain tumors. The Ewend lab has a well established group of models for testing newly developed chemotherapeutic agents that show promise in treating brain tumors. Secondly, the lab has worked together with that of Dr Charles Perou to look at the gene expression profiles of metastatic brain tumors, particularly breast cancer.
Training
Neuro-Oncology fellowship - Johns Hopkins University School of Medicine
Neurosurgery residnecy - Johns Hopkins University School of Medicine
Publications
Brem H, Ewend MG, Piantadosi S, Greenhoot J, Burger PC, Sisti M. "The Safety of Interstitial Chemotherapy with BCNU-loaded Polymer followed by Radiation Therapy in the Treatment of Newly Diagnosed Malignant Giloma," Journal of NeuroOncology 26(2):111-123, 1995.
Ewend MG, Anderson R, Tobassi K, Tyler BM, Bable KM, Williams JA, and Brem H. Local delivery of BCNU from biodegradable polymer is superior to radiation therapy in treating intracranial melanoma metastases. Owen H. Wangensteen Surgical Forum volume XLVII: 564-566, 1995.
Ewend MG, Carey LA, and Brem H. Treatment of Melanoma Metastases in the Brain (Review). Seminars in Surgical Oncology, 12:429-435, 1996.
Ewend MG, Williams JA, Tobassi K, Tyler BM, Babel KM, Anderson RC, Pinn ML, Brat DJ, and Brem H. "Local Delivery of Chemotherapy and Concurrent External Beam Radiotherapy Prolongs Survival in Metasttic Brain Tumor Models" Cancer Research, 53:5217-5223, 1996.
Olivi A, Ewend MG, Utsuki T, Tyler BM, Domb AJ, Brat DJ, and Brem. "Interstitial Delivery of Carboplatin via Biodegradable Polymers is Effective Against Experimental Giloma in the Rat. Cancer Chemotherapy and Pharmacology, 39:90-96, 1996.
Thompson RC, Pardol DM, Jaffee EM, Ewend MG, Thomas MC, Tyler BM, and Brem H. "Systemic and Local Cytokine Therapies Utilizing Transduced Tumor Cells are Synergistic in Treating Brain Tumors," Journal of Immunotherapy 19(6) 405-413, 1996.
Fung LK, Ewend MG, Sills A, Sipos EP, Thompson R, Watts M, Colvin OM, Brem H, Saltzman WM. "Pharmacokinetics of interstitial delivery of carmustine, 4-hydroperoxycyclophosphamide and paclitaxel from a biodegradable polymer implant in the monkey brain." Cancer Research 58, 672-684, 1998.
Castillo M, Ewend MG, Cush S, and Mukherji Sk. "Magnetic Resonance Imaging Appearance fo Carmustine-Impregnated implantable Wafers," International Journal of Neuroradiology 4:380-384, 1998.
Ewend MG, Sampath P, Williams JA, Tyler BM, Brem H. "Local delivery of chemotherapy prolongs survival in experimental brain metastases from breast carcinoma. Neurosurgery, 43:1185-93, 1998.
Ewend MG, Thompson RC, Anderson R, Sills, AK, Stavely O'Carrol K, Tyler BM, Hanes J, Brat D, Thomas M, Jaffee EM, Pardoll DM, Brem H. "Intracranial Paracrine Interleukin-2 Therapy Stimulates Prolonged Antitumor Immunity Which Extends Outside the Central Nervous System", Journal of Immunotherapy, 23(4): 438-448, 2000
Weaver KD, Yeyodu S, Cusack JC, Baldwin AS, And Ewend MG. "Protentiation of Chemotherapuetic Agentts Targeted Against Human Gliomas Following Antagonism of Nuclear Factor Kappa B", Submitted to Journal of Neurosurger, November 2000.
Detterbeck FC, Bleiweis MS, Ewend MG. Surgical treatment for state IV non-small cell lung cancer. IN: Detterbeck FC, Rivera MP, Socinski MA, et al (eds). Diagnosis and Treatment of Lung Cancer: an Evidence-Based Guide for the Practicing Clinician. Philadelphia: W.B. Saunders, 2000, pp 325-338.
Ewend MG, Castillo M, Weaver KD. "Mengingeal Sarcomas". In Youman's Neurological Surgery, 5th ed. Editor: HR Winn (Saunders, Philadelphia), 2000, in press (14 pages).
*Weaver KD, Wiseman DB, Farber M, Ewend MG, Marston W, Keagy BA. "Complications of lumbar drainage after thoracoabdominal aortic aneurysm repair", Journal of Vascular Surgery, 34:623-627, 2001.
*Tsai V, Kim S, Clatterbuck RE, Ewend MG, Olivi A. "Cystic prostate metastases to the brain parenchyma: report of two cases and review of the literature" Journal of Neuro-Oncology; 51:167-173, 2001.
Ewend MG, Carey LA, Morris DE, Hensing TA. "Current Treatment Options for Brain Metastases", Current Treatment Options in Oncology, 2:537-547, 2001.
Kwock L, Smith K, Castillo M, Ewend M, Cush S, Hensing T, Varia M, Morris D, Bouldin T. "Clinical Applications of Proton MR Spectroscopy in Oncology", Technology in Cancer Research & Treatment, 1 (1):1-10, 2002.
Khairi S, Ewend MG. "Current Treatment for Chordoma", Current Treatment Options in Neurology, 4(2) 167-173, 2002.
*Tamargo RJ. Rossell LA. Kossoff EH. Tyler BM. Ewend MG. Aryanpur JJ. The intracerebral administration of phenytoin using controlled-release polymers reduces experimental seizures in rats. Epilepsy Research. 48(3):145-55, 2002 Feb.
*Sonnenburg RE, White D, Ewend MG, and Senior B. Sellar Reconstruction: Is It Necessary?, Journal of Rhinology, AJR 17(6):343-346, 2003.
*Weaver KD, Ewend MG, Solander S. "Successful Transarterial Guglielmi Detachable Coil Emboliztion of Post-Traumatic Posterior Communicating Artery-Cavernous Sinus Fistula", Neurosurgery, 52(2) 458-460, 2003.
*Weaver KD, Yeyeyodu S, Cusack JC, Baldwin A, Ewend MG. "Potentiation of Chemotherapeutic Agents Following Antagonism of Nuclear Factor Kappa B in Human Glioma", Journal of Neuro-Ocnology, 61(3) 187-196, 2003.
*Carey LA, Ewend MG, Metzger R, Sawyer L, Dees EC, Sartor CI, Moore DT, Graham MG. Central nervous system metastases in women after multimodality therapy for high risk breast cancer. Breast Cancer Research and Treatment, In Press, 2004.
E-mail: ewend@med.unc.edu
Telephone: (919) 966-1374
FAX: (919) 966-6627
Address: CB# 7060 Chapel Hill, NC
