Last Updated: 7/3/2009

Research Interests
Dr. Ball's laboratory is focused on understanding the mechanisms by which the body metabolises exogenous chemicals to reactive species that can damage DNA and other important cellular macromelecules, and thereby trigger alterations in cell growth that lead to cancer. Current research is directed particularly to characterization of the DNA modifications resulting from reactive oxygen species. Major past accomplishments include development of assays for biomarkers of exposure and elucidation of the importance of the gut flora in generating reactive intermediates from nitrated polycyclic aromatic hydrocarbons.

Training
University of Bristol, Bristol, U.K., B.Sc., 1972, Biochemistry
St Mary's Hospital Medical School, University of London, London, U.K., Ph.D., 1976, Biochemistry
National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA Post-doctoral Fellowship, 1976-1979, Biochemical Toxicology

Publications
Ye W., Sangaiah R., Degen D.E., Gold A.., Jayaraj K., Koshlap K.M., Boysen G., Williams J., Tomer K.B., Mocanu V., Dicheva D., Parker C.E., Schaaper R.M. and Ball L.M.(2009). An Iminohydantoin Lesion Induced in DNA by Peracids and Other Epoxidizing Oxidants. J. Amer. Chem. Soc., May 6;131(17):6114-23. PMID: 19354244

Kim S., Collins L.B., Boysen G., Swenberg J.A., Gold A., Ball L.M., Bradford B.U., Rusyn I. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology. 2009 Jun 20. [Epub ahead of print] PMID: 19549554

Lu K, Ye W, Gold A,. Ball LM and Swenberg JA. Formation of S-[1-(N2-Deoxyguanosinyl)methyl]glutathione between Glutathione and DNA Induced by Formaldehyde. J. Amer. Chem. Soc. 131(10):3414-3415, 2009. DOI:10.1021/ja808048c.

Park J, Ball LM, Richardson SD, Zhu HB, Aitken MD.: Oxidative Mutagenicity Of Polar Fractions From Polycyclic Aromatic Hydrocarbon-Contaminated Soils. Environ Toxicol Chem., 27(11):2207-2215, 2008. PMID: 18517307.

Kang-Sickel, J.-C. C., Fox, D.D., Nam, T.-g., Jayaraj, K., Ball, L.M., French, J.E., Klapper, D.G., Gold, A. and Nylander-French, L.A.: S-Arylcysteine-Keratin Adducts as Biomarkers of Human Dermal Exposure to Aromatic Hydrocarbons. Chem. Res. Toxicol., 21, 852-858, 2008.

Ye, W., Sangaiah, R., Degen, D.E., Gold, A., Jayaraj, K., Koshlap, K.M., Boysen, G., Williams, J., Tomer, K.B., and Ball, L.M. A 2-Iminohydantoin from the Oxidation of Guanine. Chem Res Toxicol. 19(4):506-510, 2006.

E-mail: lmball@unc.edu
Telephone: (919) 966-7306
FAX: (919) 966-7911
Address: 158 Rosenau Hall Chapel Hill, NC 27599-7431

Click here to update this profile