Cancer Cell Biology

The Cancer Cell Biology Program emphasizes cancer-related basic and translational research in the following areas:

• Cell cycle regulation and tumor suppression
• Cell adhesion
• Cell signaling by growth factors and receptors
• Chromatin regulation and epigenetics
• Angiogenesis and vascular biology

Fundamental research into these five core areas provides critical insights into cancer development and, more importantly, targets and tools for therapeutic intervention.  The Program fosters integrated research that spans these inter-related themes, enhancing the capabilities of Program members through the establishment or expansion of appropriate core facilities, and promoting interactions with investigators from other Lineberger Cancer Center basic, clinical and population science programs.

The Program is led by Dr. Yue Xiong, professor of Biochemistry & Biophysics, a Program member since 1993 and Leader since 2006. He is known for his studies of cell cycle control, tumor suppression and the ubiquitin pathway.