Specialized Program of Research Excellence (SPORE) in Breast Cancer
Researchers,
clinicians and public health specialists at UNC and UNC Lineberger are working
diligently to find new ways of detecting, treating and preventing breast cancer.
Their work begins with the National Cancer Institute-funded Specialized Program
of Research Excellence (SPORE) in Breast Cancer, one of eleven in the country.
Originally funded in 1992, the UNC SPORE in Breast Cancer has created an outstanding
program in translational research. Its current five projects are conceptually
linked by studies of breast cancer molecular phenotypes, particularly those with
the worst prognosis: basal-like tumors, luminal B tumors, and tumors that overexpress
HER2. These projects are led by basic and clinical science teams and include
the following:
Carolina Breast Cancer Study: Genetic susceptibility for breast cancer
subtypes in African Americans and whites
Breast cancer vaccine strategies for HER2 and luminal B tumors
Determination of breast cancer subtype sensitivities to standard chemotherapy
and combination chemotherapy-biologic regimens
Molecular portraits of human breast cancer endothelium
HER4 Isoforms: Tumor suppressor action and prognostic significance
Researchers involved in SPORE Breast Cancer projects include the following:
Researchers,
clinicians and public health specialists at UNC and UNC Lineberger are working
diligently to find new ways of detecting, treating and preventing breast cancer.
Their work begins with the National Cancer Institute-funded Specialized Program
of Research Excellence (SPORE) in Breast Cancer, one of eleven in the country.
