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Pei, X.H., Bai, F., Smith, M.D., Usary, J., Fan, C., Pai, S-Y., Ho, I.C., Perou, C.M., and Xiong, Y. (2009). CDK Inhibitor p18INK4c is a Downstream Target of GATA3 and Restrains Mammary Luminal Progenitor Cell Proliferation and Tumorigenesis. Cancer Cell 15:38-401. Read Article   Zhao, S., Lin, Y., Xu, W., Jiang, W., Zha, Z., Wang, P., Yu, W., Li, Z., Gong, L., Peng, Y., Ding, J., Lei, Q., Guan, K-L, Xiong, Y. (2009) Glioma-derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1a. Science 325(5924):261-265. Read Article   Kotake, Y. Zeng, Y., Xiong, Y. (2009) DDB1-CUL4 and MLL1 Mediate Oncogene-Induced p16INK4a Activation. Cancer Research 69(5):1809-14. Read Article    McCall, C.M., Miliani de Marval, P.L., Chastain, P.D. II, Jackson, S.C., He, Y.J., Kotake, Y., Cook, J.G., Xiong, Y. (2008) HIV-1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Molecular and Cellular Biology 28(18):5621-33. Read Article   Zhang, Y., Feng, S., Chen, F., Chen, H., Wang, J., McCall, C., Xiong Y., Deng, X.W. (2008) Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 Forms a Nuclear E3 Ubiquitin Ligase with DDB1 and CUL4 That Is Involved in Multiple Plant Developmental Processes. The Plant Cell 20(6):1437-1455. Read Article   Hu, J., Zacharek, S., He, Y.J., Lee, H., Shumway, S., Duronio, R.J., Xiong, Y. (2008) WD40 Protein FBW5 Promotes Ubiquitination of Tumor Suppressor TSC2 by DDB1-CUL4-ROC1 Ligase. Genes & Development 22(7):866. Read Article   Lei, Q.Y., Zhang, H., Zhao, B., Zha, Z.Y., Bai, F., Pei, X.H., Zhao, S., Xiong, Y., Guan, K.L. (2008) TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway. Molecular and Cellular Biology 20(1):152-67. Read Article   Lee, J.H., Terzaghi, W., Gusmaroli, G., Charron, J.B., Yoon, H.J., Chen, H., He, Y.J., Xiong, Y., Deng, X.W. (2008) Characterization of Arabidopsis and Rice DWD Proteins and Their Roles as Substrate Receptors for CUL4-RING E3 Ubiquitin Ligases. Plant Cell 28(7):2426-36. Read Article    Ramsey, M.R., Krishnamurthy, J., Pei, X.H., Torrice, C., Lin, W., Carrasco, D.R., Ligon, K.L., Xiong, Y., and Sharpless, N.E. (2007) Expression of p16Ink4a Compensates for p18Ink4c Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and Tissues. Cancer Research 67:4732-4741. Read Article   Pei, X.H., Bai, F., Smith, M.D., Xiong, Y. (2007) p18Ink4c Collaborates with Men1 to Constrain Lung Stem Cell Expansion and Suppress Non–Small-Cell Lung Cancers. Cancer Research 67:3162-3170. Read Article   Bai, F., Pei, X.H., Nishikawa, T., Smith, M.D., Xiong, Y. (2007) p18Ink4c, but Not p27Kip1, Collaborates with Men1 To Suppress Neuroendocrine Organ Tumors. Molecular and Cellular Biology 27:1495-504. Read Article   Kotake, Y., Cao, R., Viatour, P., Sage, J., Zhang, Y., Xiong, Y. (2007) pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene. Genes & Development 21:49-54. Read Article    He, Y. J., McCall, C.M., Zeng, Y., Xiong, Y. (2006) DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4–ROC1 ubiquitin ligases. Genes & Development 20:2949-2954. Read Article   Bai, F., Pei, X.H., Pandolfi, P.P. , Xiong Y. (2006) p18Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control. Molecular and Cellular Biology 26:4564-4576. Read Article   Wang, H., Zhai, L., Xu, J., Joo, H.Y., Jackson, S., Erdjument-Bromage, H., Tempst, P., Xiong, Y., Zhang, Y. (2006) Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Molecular Cell 22:383-94. Read Article   Andrews, P., He, Y.J., Xiong, Y. (2006) Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. Oncogene 25(33):4534-48. Read Article  Hu, J., Xiong, Y. (2006) An evolutionarily-conserved function of PCNA for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. Journal of Biological Chemistry 281:3753-3756. Read Article     Zacharek, S.J., Xiong, Y., Shumway S.D. (2005) Negative regulation of TSC1-TSC2 by mammalian D-type cyclins. Cancer Research 65:11354-11360. Read Article   Karnik, S.K., Hughes, C.M., Gu, X., Rozenblatt-Rosen, O., McLean, G.W., Xiong, Y., Meyerson, M., Kim, S.K. (2005) Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4C. Proceedings of the National Academy of Science 102:14659-64. 24:6653-6664. Read Article  Furukawa, M., Xiong, Y. (2005) BTB protein Keap1 targets the antioxidant transcription factor Nrf2 for ubiquitination by the cullin 3-Roc1 ligase. Molecular and Cellular Biology 25:162-171. Read Article    Hu, J., McCall, C.M., Ohta, T., Xiong, Y. (2004) Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nature Cell Biology 6:1003-1010. Read Article  Goldenberg, SL, Cascio, TC, Shumway, SD , Garbutt, KC, Liu, J, Xiong, Y., Zheng, N. (2004) Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multi-subunit cullin-based ubiquitin ligases. Cell 119:517-528. Read Article   Pei, XH, Bai, F., Tsutsui, T., Kiyokawa, H., Xiong, Y. (2004) Genetic evidence for functional dependency of p18Ink4c on CDK4. Molecular and Cellular Biology24:6653-6664. Read Article  Feng, S., Shen Y., Sullivan, J.A., Rubio, V., Xiong, Y., Sun, T.P., Deng, X.W. (2004) The Arabidopsis thaliana CAND1, an unmodified CUL1 interacting protein, is involved in multiple development pathways controlled by ubiquitin/proteasome-mediated protein degradation. Plant Cell 16:1870-1882. Read Article    Zhang, Y, Whitewolf, G., Allio, T., Jin, A., Bhat, K., Burkhart, W., Xiong, Y. (2003). Ribosomal protein L11 binds to and negatively regulates oncoproteins HDM2. Molecular and Cellular Biology 23:8902-8912. Read Article   Furukawa, M., He, Y.J., Borchers, C., Xiong, Y. (2003). Targeting protein ubiquitination by BTB-cullin 3-Roc1 ubiquitin ligases. Nature Cell Biology 5:1001-1007. Read Article  Michel, J.J., McCarville, J., Xiong, Y. (2003). A role for Saccharomyces cerevisiae CUL7 ubiquitin ligase in proper anaphase progression. Journal of Biological Chemistry 278:22828-22837. Read Article   Shumway, S.D. , Li Y., Xiong, Y. (2003). 14-3-3 beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin. Journal of Biological Chemistry 278:2089-2092. Read Article   Bai, F., Pei , X.H., Godfrey, V.L., Xiong, Y. (2003). Haploinsufficiency of p18INK4csensitizes mice to carcinogen-induced tumorigenesis. Molecular and Cellular Biology 23:1269-1277. Read Article    Liu, J., Furukawa, M., Matsumoto,T., Xiong, Y. (2002). NEDD8 modification of CUL1 dissociates p120CAND1, an inhibitor of CUL1-SKP1 binding and SCF ligases. Molecular Cell 10:1511-1518. Read Article   Yarbrough, W.G., Bessho, M., Zanation, A., Bisi, J.E., Xiong, Y. (2002). Human tumor suppressor ARF impedes S-phase progression independent of p53. Cancer Research 62:1171-1177. Read Article  Furukawa, M., Ohta, T., Xiong, Y. (2002). Activation of UBC5 ubiquitin conjugating (E2) enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. Journal of Biological Chemistry 277:15758-15765. Read Article    Zhang, Y., and Xiong, Y. (2001). A role of p53 N-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation. Science 292:1910-1915. Read Article   Ohta, T., and Xiong, Y. (2001). Phosphorylation- and SKP1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases. Cancer Research 61:1347-1353. Read Article    Furukawa, M., Zhang, Y., McCarville, J., Ohta, T., and Xiong, Y. (2000). The CUL1 C-terminal sequence and ROC1 promote nuclear accumulation and NEDD8 modification of CUL1, resulting in efficient ubiquitin ligase activity. Molecular and Cellular Biology 20:8185-8197. Read Article  Franklin, D.S., Godfrey, V.L., O’Brien, D.A., Deng, C., and Xiong, Y. (2000). Functional collaboration between different CDK inhibitors suppress tumor growth with distinct tissue specificity. Molecular and Cellular Biology 20:6147-58. Read Article    Ohta, T., Michel, J., and Xiong, Y. (1999). Association with cullin partners protects ROC proteins from proteasome-dependent degradation. Oncogene 18:6756-6766. Read Article   Zhang, Y., and Xiong, Y. (1999). Tumor derived mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Molecular Cell 3:579-591. Read Article  Ohta, T., Michel, J. J., Schottelius, A. J., and Xiong, Y. (1999). ROC1, a homologue of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Molecular Cell3:535-541. Read Article     Zariwala, M. Liu, J., and Xiong, Y. (1998). Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. Oncogene17:2787-2798. Read Article   Franklin D. S., Godfrey, V. L., Lee, H., Kovalev, G. I., Schoonhoven,R., Chen-Kiang, S., Su, L., and Xiong, Y. (1998). CDK inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes & Development 12:2899-2911. Read Article   Phelps, D. E., and Xiong, Y. (1998). Regulation of CDK4 during adipogenesis involves switching of cyclin D subunits and concurrent binding of p18INK4c and p27Kip1. Cell Growth Differentiation. 9:595-610. Read Abstract   Michel, J., and Xiong, Y. (1998) Human cullin 1, but not other cullin family members, selectively interacts with SKP1 to form a complex withSKP2 and cyclin A. Cell Growth Differentiation 9:439-445. Read Article  Zhang, Y., Xiong, Y., and Yarbrough, W. G. (1998). ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92:725-734. Read Article    Watanabe, H., Pan, Z-Q., Schreiber-Agus, N., DePinho, R. A., Hurwitz, J., and Xiong, Y. (1998). Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen. Proceedings of the National Academy of Science 95:1392-1397. Read Article    Phelps, D., Hsiao, K-M., Li, Y., Hu, N., Franklin , D. S., Westphal, E.,Lee, E., and Xiong, Y. (1998). Coupled transcriptional and translational control of CDK inhibitor p18INK4cs expression during myogenesis. Molecular and Cellular Biology 18:2334-2343. Read Article    Zariwala, M. and Xiong, Y. (1996). Lack of mutation in the cyclin-dependent kinase inhibitor, p19INK4d, in tumor-derived cell lines and primary tumors. Oncogene 13:2033-2038.   Franklin, D. F. and Xiong, Y. (1996). Induction of CDK inhibitor p18 and its predominant association with CDK4 and CDK6 during myogenic differentiation. Molecular Biology of the Cell 7:1587-1599. Read Abstract    Xiong, Y., Kuppuswamy, D., Li, Y., Livanos, E.M., Hixon, M., White,A., Beach, D., and Tlsty, T. D. (1996). Alteration of cell cycle kinase complexes in human papilloma virus E6- and E7-expressing fibroblasts precedes neoplastic transformation. Journal of Virology 70:999-1008. Read Abstract    Zariwala, M., Liu, E., and Xiong, Y. (1996). Mutational analysis of the p16 family cyclin-dependent kinase inhibitors p15MTS2/INK4b and p18 in tumor-derived cell lines and primary tumors. Oncogene 12:451-455.     Guan, K-L., Jenkins, C., Li, Y., O'Keefe, C.L., Zariwala, M., Noh, S., and Wu, X., Matera , A. G. and Xiong, Y. (1996) Isolation and Characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. Molecular Biology of the Cell 7:57-70. Read Abstract    Yee, A., Nichols, M. A., Wu, L., Hall, F. L., Kobayashi, R. and Xiong, Y. (1995). Molecular cloning of CDK7-associated human MAT1, a CDK-activating kinase (CAK) assembly factor. Cancer Research 55:6058-6062     Guan, K-L., Jenkins, C. W., Li, Y., Nichols, M. A., Wu, X., O'Keefe, C. L., Matera, G. and Xiong, Y. (1994). Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes& Development 8:2939-2952. Read Abstract    Li, Y., Nichols, M. A., Shay, J. W., and Xiong, Y. (1994). Transcriptional repression of the cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product, pRb. Cancer Research 54:6078-6082.     Li, Y., Jenkins, C., Nichols, M., and Xiong, Y. (1994). Cell Cycle Expression and p53 Regulation of the Cyclin-Dependent Kinase Inhibitor p21. Oncogene 9:2261-2268.   Reviews and Book Chapters: Jackson, S. and Xiong, Y. (2009) Targeting Protein Ubiquitylation: DDB1 Takes Its RING Off. Nature Cell Biology 11(4):379-81. Read Article Shumway, S.D. and Xiong, Y. (2006) Twice Primed: Cyclin E Is Phosphorylated and Isomerized Before Being Ubiquitinated. Molecular Cell 23:149-153. Read Article Xiong, Y. and Kotake Y. (2006) No exit strategy? No problem: APC inhibits beta-catenin inside the nucleus.  Genes & Development 20:637-642. Read Article Pei, X, and Xiong, Y. (2005) Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issues. Oncogene 18:2787-2795. Read Article McCall, CM, Hu, J, Xiong, Y.  (2005) Recruiting substrates to Cullin 4-dependent ubiquitin ligases by DDB1. Cell Cycle 4:27-29. Read Article Furukawa, M, Andrews, P, and Xiong, Y. (2005) Assays for RING family ubiquitin ligases. Methods in Molecular Biology 301:37-46. Zhang, Y. and Xiong, Y. (2001). Control of p53 ubiquitination and nuclear export by MDM2 and ARF. Cell Growth & Differentiation 12:175-186. Read Article Yarbrough, W, and Xiong, Y. (2001) INK4a and ARF: crossroads of tumorigenesis. Encyclopedia of Cancer, Second edition (Bertino ed.), Academic Press. Phelps, D. and Xiong, Y. (1996). Assay for activity of mammalian cyclin D-dependent kinases   CDK4 and CDK6. Method in Enzymology, W. Dunphy ed. 283:194-205.